Malignant Hyperthermia is always a concern

The background of participants are as follows:

BIOS
Dr Mike Greenberg
Barry Miller
Debbie Conn

For further information, email addresses are placed under Resources on this website.
EAGLE PHARMACEUTICALS

NANOSUSPENSION TECHNOLOGY FOR RAPID RECONSTITUTIONAND ADMINISTRATION1,4

• Advanced nanosuspension     technology is combined with a lyophilized formulation that allows     RYANODEX® to be reconstituted with sterile water for injection and     administered in significantly less time compared with other formulations     of dantrolene sodium1,4

 
• Simplified and rapid      reconstitution to prepare a single vial within 10 seconds1,4
 
• Time to administer 2.5 mg/kg      loading dose of RYANODEX® for a 100 kg patient is 1 minute compared to      >22 minutes for other approved formulations1,4*

*Based on administration speed of 50 mL/min (16.5 mg/min).1

FEWER VIALS AND LESS STERILE WATER FOR INJECTION

• RYANODEX® requires fewer vials     (depending on the patient) and less sterile water for injection volume     compared to other dantrolene formulations5-7

 
• One vial of RYANODEX® contains      the same amount of dantrolene sodium as 12.5 vials of other approved      formulations5-7
 
• Each vial of RYANODEX®      contains 250 mg of dantrolene sodium and requires reconstitution with      only 5 mL of sterile water for injection vs 60 mL per vial with      other formulations1,5-7

RAPID RESPONSE THAT CAN HELP MITIGATE RISK OFCOMPLICATIONS1

• Treating patients with     dantrolene sodium quickly is essential to help minimize or avoid serious     complications including coma, cardiac arrest, and disseminated     intravascular coagulation2,4

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